Minimum Rim Width and Lamina Cribrosa Depth in Non-Glaucomatous and Glaucomatous U.S. Veterans
Medical Subject Headings
Glaucoma; Optic Disk; Visual Fields; Cross-Sectional Studies; Veterans
Purpose: Assess the utility of the MRW and lamina cribrosa depth measurements for detecting differences between non-glaucomatous and glaucomatous U.S. Veterans. Compare inter-eye differences of individuals with glaucoma.
Method: 38 subjects were recruited per group: Group 1 included one eye of non-glaucomatous participants, and Group 2 included each qualifying eye of participants with glaucoma. Analysis compared Group 1 with the more affected eye only of Group 2 participants, and separately between the more and less affected eyes of group 2 participants. MRW measurements were obtained with Heidelberg Eye Explorer© (HEYEX). Average lamina cribrosa depths were measured manually utilizing HEYEX.
Results: 26 subjects from Group 1 and 33 subjects from Group 2 were included. A significantly thinner MRW was found in glaucomatous eyes vs. non-glaucomatous eyes (210 µm vs. 309 µm; P < .001). The normative database in HEYEX had an 85% sensitivity and 92% specificity to detect glaucomatous nerves. Among the 27 participants in Group 2 who had both eyes tested, eyes with more advanced visual field loss showed significantly thinner global MRW compared to fellow eyes (203 µm vs. 224 µm P = .03). Lamina cribrosa depths were non-significantly deeper in glaucomatous vs. non-glaucomatous eyes (476 µm vs. 429 µm P = .17).
Conclusions: The MRW parameter differentiates between glaucomatous and non-glaucomatous optic nerves. Lamina cribrosa depths were non-significantly deeper in glaucomatous vs. non-glaucomatous participants. Post-hoc inter-eye data analysis suggested that inter-eye differences in gMRW values of glaucomatous eyes reflect asymmetric damage as correlated with the visual field
Hillard J, Druckenbrod R, Asefzadeh B. Minimum Rim Width and Lamina Cribrosa Depth in Non-Glaucomatous and Glaucomatous U.S. Veterans. Optometric Clinical Practice. 2022; 4(2):27. doi: 10.37685/uiwlibraries.2575-7722.214.171.1246. https://doi.org/10.37685/uiwlibraries.2575-77126.96.36.1996
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