Alternative Therapies for Treatment of Keratoconjunctivitis Sicca Associated with Sjogren's Syndrome
Medical Subject Headings
Keratoconjunctivitis sicca-- therapy, Sjogren's syndrome
Background: Sjogren’s syndrome is a chronic, systemic autoimmune disorder, which often results in significant ocular surface disease. Dry eye associated with Sjogren’s syndrome is a multifactorial disease which leads to decreased function of the lacrimal glands and altered tear composition. There currently are numerous anti-inflammatory methods used for treatment of this disease.
Case Report: This case report will focus on the use of amniotic membrane placement and autologous serum tears to facilitate a successful scleral contact lens fit allowing for reduced ocular inflammation and discomfort associated with Keratoconjunctivitis sicca due to Sjogren’s syndrome.
Conclusion: Clinical management of keratoconjunctivitis sicca due to Sjogren’s syndrome can be challenging. Diagnosis often requires numerous in office testing including Schirmer I/II, TBUT, sodium fluorescein stain, and osmolarity. Such testing can be repeated over time to monitor for improvement with addition of each new therapy. Various treatment modalities such as topical lubricants, cyclosporine, autologous serum tears, or amniotic membranes have been proven to provide short-term benefits and excellent maintenance of symptoms. Utilizing such treatments to promote an ideal scleral contact lens fit provides lasting benefits of corneal clarity and stable vision.
Brady BM, Man MK. Alternative Therapies for Treatment of Keratoconjunctivitis Sicca Associated with Sjogren's Syndrome. Optometric Clinical Practice. 2020; 2(2):12. doi:10.37685/uiwlibraries.2575-7722.214.171.1243. https://doi.org/10.37685/uiwlibraries.2575-77126.96.36.1993
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