Date of Degree
Master of Science (MS)
William F. MacKenzie
Donald D. McLain
It has been noted that hematoxylin-eosin stained surface cells in the transitional epithelium of certain animals occasionally contain acidophilic inclusion bodies. These can be observed in monkey kidney pelvis, ureter, urinary bladder, and urethra. In one species of monkey, Macaca fascicularis, the inclusion bodies are quite prevalent and apparently are not related to any pathologic or experimental condition. They are highly refractile under the light microscope, a property which often indicates structures below the resolving power of the microscope. This study was designed to explore the composition and structure of these inclusion bodies. Procedures were selected to detect the presence of lysosomes, viruses, proteins, lipids, and carbohydrates and these histochemical studies were correlated with electron microscopic examinations. Results of these analyses support the conclusion that these bodies are keratin.
Weckerling, Alan B., "Ultrastructure of Inclusion Bodies in the Transitional Epithelium of Monkey Urinary Bladder" (1973). Theses & Dissertations. 289.